Diabetes mellitus negatively affects peri-implant bone formation in the diabetic domestic pig

J Clin Periodontol. 2011 Aug;38(8):771-9. doi: 10.1111/j.1600-051X.2011.01746.x.


Aim: Diabetes mellitus is classified as a relative contraindication for implant treatment, and higher failure rates have been seen in diabetic patients. The aim of the present study was to investigate the effect of diabetes on peri-implant bone formation in an animal model of human bone repair.

Materials and methods: Diabetes was induced by an intra-venous application of streptozotocin (90 mg/kg) in 15 domestic pigs. Implants were placed after significant histopathological changes in the hard and soft tissues were verified. The bone-implant contact (BIC), peri-implant bone mineral density (BMD), and expression of collagen type-I and osteocalcin proteins were qualitatively evaluated 4 and 12 weeks after implantation. Fifteen animals served as healthy controls.

Results: Diabetes caused pathological changes in the soft and hard tissues. The BIC and BMD were significantly reduced in the diabetic group after 4 and 12 weeks. Collagen type-I was increased in the diabetic group at both time points, whereas osteocalcin was reduced in the diabetic group.

Conclusions: Poorly controlled diabetes negatively affects peri-implant bone formation and bone mineralization. These findings have to be taken into consideration for diabetic patients with an indication for implant therapy.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Density / physiology
  • Bone Remodeling / physiology
  • Calcification, Physiologic / physiology
  • Collagen Type I / analysis
  • Coloring Agents
  • Dental Implants*
  • Dermatologic Surgical Procedures
  • Diabetes Mellitus, Experimental / pathology
  • Diabetes Mellitus, Experimental / physiopathology*
  • Disease Models, Animal
  • Ear, External / blood supply
  • Endothelium, Vascular / pathology
  • Frontal Bone / pathology
  • Frontal Bone / physiopathology
  • Frontal Bone / surgery
  • Immunohistochemistry
  • Microradiography
  • Microscopy, Electron, Scanning
  • Osteocalcin / analysis
  • Osteogenesis / physiology*
  • Periosteum / pathology
  • Periosteum / physiopathology
  • Periosteum / surgery
  • Skin / pathology
  • Skin / physiopathology
  • Streptozocin
  • Swine
  • Time Factors
  • Wound Healing / physiology


  • Collagen Type I
  • Coloring Agents
  • Dental Implants
  • Osteocalcin
  • Streptozocin