PD-L2 is expressed on activated human T cells and regulates their function

Mol Immunol. 2011 Sep;48(15-16):2214-9. doi: 10.1016/j.molimm.2011.06.436. Epub 2011 Jul 12.


T-cell activation and proliferation are regulated by cosignaling adhesion molecules involved in positive or negative signals. Programmed death (PD)-1 is one of immune inhibitory molecules that is expressed in activated T cells and is a promising target for immunotherapy. Both PD-1 ligands, PD-L1 and PD-L2 are expressed on antigen presenting cells (APCs) involved in the dialogue between a T cell and an APC. Here, we analysed the expression of these ligands, especially for PD-L2, on T cells. PD-L2 appears to be expressed on activated CD4 and CD8T cell subsets. Moreover, as PD-1 molecule, PD-L2 engagement at the surface of T cells is able to down-modulate cytokine production and cell proliferation. These observations indicate that PD-L2 is expressed following activation and is involved in the regulation of T cell function, highlighting the level of complexity in the T cell cosignaling network.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • B7-1 Antigen / biosynthesis
  • B7-1 Antigen / immunology*
  • Cell Separation
  • Cytokines / biosynthesis
  • Cytokines / immunology
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Flow Cytometry
  • Humans
  • Lymphocyte Activation / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Programmed Cell Death 1 Ligand 2 Protein
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / metabolism*


  • B7-1 Antigen
  • Cytokines
  • PDCD1LG2 protein, human
  • Pdcd1lg2 protein, mouse
  • Programmed Cell Death 1 Ligand 2 Protein