Chronic (neuropathic) corneal pain and blepharospasm: five case reports

Pain. 2011 Oct;152(10):2427-2431. doi: 10.1016/j.pain.2011.06.006. Epub 2011 Jul 12.


Pain and focal dystonias have been associated with chronic pain conditions such as complex regional pain syndrome. Corneal pain, frequently known as "dry eye", may be a neuropathic pain condition with abnormalities of the nerve plexus. Here we present 5 case histories of patients with defined corneal pain (with associated neuropathic features) and objective measures of changes in the nerve plexus and associated blepharospasm. A putative relationship between pain and blepharospasm suggests potential involvement of the basal ganglia in both these conditions.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Basal Ganglia / physiopathology
  • Blepharospasm / complications*
  • Blepharospasm / physiopathology
  • Chronic Pain / complications*
  • Chronic Pain / physiopathology
  • Cornea / innervation
  • Corneal Diseases / etiology*
  • Corneal Diseases / physiopathology
  • Female
  • Humans
  • Hypesthesia / etiology*
  • Hypesthesia / physiopathology
  • Male
  • Middle Aged
  • Neuralgia / complications*
  • Neuralgia / physiopathology