Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects in a single case double-blind trial

Eur Arch Psychiatry Clin Neurosci. 1990;240(1):1-4. doi: 10.1007/BF02190083.


A double-blind study was performed comparing 5 mg delta-9-tetrahydrocannabinol (THC) p.o., 50 mg codeine p.o., and placebo in a patient with spasticity and pain due to spinal cord injury. The three conditions were applied 18 times each in a randomized and balanced order. Delta-9-THC and codeine both had an analgesic effect in comparison with placebo. Only delta-9-THC showed a significant beneficial effect on spasticity. In the dosage of THC used no altered consciousness occurred.

Publication types

  • Case Reports
  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Double-Blind Method
  • Dronabinol / administration & dosage*
  • Ependymoma / surgery*
  • Humans
  • Male
  • Neurologic Examination
  • Pain Measurement
  • Paraparesis, Tropical Spastic / drug therapy*
  • Paresthesia / drug therapy*
  • Postoperative Complications / drug therapy*
  • Spinal Cord Neoplasms / surgery*


  • Dronabinol