Antioxidant, electrochemical, thermal, antimicrobial and alkane oxidation properties of tridentate Schiff base ligands and their metal complexes

Spectrochim Acta A Mol Biomol Spectrosc. 2011 Oct 15;81(1):184-98. doi: 10.1016/j.saa.2011.05.106. Epub 2011 Jun 21.

Abstract

In this study, two Schiff base ligands (HL(1) and HL(2)) and their Cu(II), Co(II), Ni(II), Pd(II) and Ru(III) metal complexes were synthesized and characterized by the analytical and spectroscopic methods. Alkane oxidation activities of the metal complexes were studied on cyclohexane as substrate. The ligands and their metal complexes were evaluated for their antimicrobial activity against Corynebacterium xerosis, Bacillus brevis, Bacillus megaterium, Bacillus cereus, Mycobacterium smegmatis, Staphylococcus aureus, Micrococcus luteus and Enterococcus faecalis (as gram-positive bacteria) and Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Yersinia enterocolitica, Klebsiella fragilis, Saccharomyces cerevisiae, and Candida albicans (as gram-negative bacteria). The antioxidant properties of the Schiff base ligands were evaluated in a series of in vitro tests: 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and reducing power activity of superoxide anion radical generated non-enzymatic systems. Electrochemical and thermal properties of the compounds were investigated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkanes / metabolism*
  • Anti-Infective Agents / analysis
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / pharmacology
  • Antioxidants / analysis
  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Coordination Complexes / analysis
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacology*
  • Differential Thermal Analysis
  • Electrochemistry
  • Gram-Negative Bacteria / drug effects
  • Gram-Negative Bacteria / growth & development
  • Gram-Positive Bacteria / drug effects
  • Gram-Positive Bacteria / growth & development
  • Humans
  • Ligands
  • Microbial Sensitivity Tests
  • Models, Biological
  • Molecular Structure
  • Oxidation-Reduction / drug effects
  • Schiff Bases / analysis
  • Schiff Bases / chemistry
  • Schiff Bases / pharmacology*
  • Structure-Activity Relationship

Substances

  • Alkanes
  • Anti-Infective Agents
  • Antioxidants
  • Coordination Complexes
  • Ligands
  • Schiff Bases