New form of administering chlorhexidine for treatment of denture-induced stomatitis

Ther Clin Risk Manag. 2011:7:219-25. doi: 10.2147/TCRM.S18297. Epub 2011 Jun 14.


Background: The purpose of this study was to evaluate the release of chlorhexidine as an antifungal drug from doped self-cured poly (methyl methacrylate) (PMMA) acrylic resin and the effect of the drug released on the growth of Candida albicans.

Methods: Release of chlorhexidine was evaluated using liquid chromatography, and the effect of the drug on the growth of C. albicans was investigated microbiologically using a "well" technique on Saboraud culture medium inoculated with a resistant strain of C. albicans.

Results: Chlorhexidine leached steadily out of the acrylic resin into distilled water at mouth temperature, and the sustained drug release continued throughout the 28-day test period. The drug released also demonstrated antifungal activity against the resistant strain of C. albicans.

Conclusion: The findings of this study support the use of chlorhexidine-impregnated self-cured PMMA chair-side resin as a new dosage form for the treatment of denture-induced stomatitis.

Keywords: Candida albicans; antifungal drug; chlorhexidine; denture stomatitis; eluates; poly (methyl methacrylate).