Transient receptor potential canonical channels in angiogenesis and axon guidance

Cell Mol Life Sci. 2011 Dec;68(23):3815-21. doi: 10.1007/s00018-011-0755-x. Epub 2011 Jul 14.


Wiring of vascular and neural networks requires precise guidance of growing blood vessels and axons, respectively, to reach their targets during development. Both of the processes share common molecular signaling pathways. Transient receptor potential canonical (TRPC) channels are calcium-permeable cation channels and gated via receptor- or store-operated mechanisms. Recent studies have revealed the requirement of TRPC channels in mediating guidance cue-induced calcium influx and their essential roles in regulating axon navigation and angiogenesis. Dissecting TRPC functions in these physiological processes may provide therapeutic implications for suppressing pathological angiogenesis and improving nerve regeneration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Axons / metabolism*
  • Humans
  • Neovascularization, Physiologic*
  • Nerve Regeneration
  • TRPC Cation Channels / genetics
  • TRPC Cation Channels / metabolism*


  • TRPC Cation Channels