Genetic factors associated with age-related macular degeneration

Nicolas Leveziel; Julien Tilleul; Nathalie Puche; Jennyfer Zerbib; Franck Laloum; Giuseppe Querques; Eric H Souied

doi:10.1159/000328981

Genetic factors associated with age-related macular degeneration

Ophthalmologica. 2011;226(3):87-102. doi: 10.1159/000328981. Epub 2011 Jul 14.

Authors

Nicolas Leveziel¹, Julien Tilleul, Nathalie Puche, Jennyfer Zerbib, Franck Laloum, Giuseppe Querques, Eric H Souied

Affiliation

¹ Department of Ophthalmology, Hôpital Intercommunal de Créteil, University of Paris XII, Créteil, France. nicolas.leveziel@chicreteil.fr

PMID: 21757876
DOI: 10.1159/000328981

Abstract

Age-related macular degeneration (AMD) is a complex, multifactorial disease associated with environmental and genetic factors. This review emphasizes the clinical impact of the major genetic factors mainly located in the complement factor H gene and on the 10q26 locus, and their current and future implications for the management of AMD.

Publication types

Review

MeSH terms

Chromosomes, Human, Pair 10 / genetics*
Complement Factor H / genetics
High-Temperature Requirement A Serine Peptidase 1
Humans
Macular Degeneration / genetics*
Proteins / genetics
Serine Endopeptidases / genetics

Substances

ARMS2 protein, human
CFH protein, human
Proteins
Complement Factor H
High-Temperature Requirement A Serine Peptidase 1
HTRA1 protein, human
Serine Endopeptidases