Epidemiology and prevention of hepatitis B virus infection

Korean J Hepatol. 2011 Jun;17(2):87-95. doi: 10.3350/kjhep.2011.17.2.87.


Hepatitis B virus (HBV) infection has been a major global cause of morbidity and mortality. The recognition of the problem led to a worldwide effort to reduce transmission of HBV through routine infant vaccination. HBV infection is the most common cause of chronic liver diseases and hepatocellular carcinoma in Korea. After hepatitis B vaccine era, seroprevalence of hepatits B surface antigen is decreasing, particularly in children. Hepatitis B vaccine is remarkably safe and shows high immunogenicity. Universal childhood immunization with three doses of hepatitis B vaccine in the first year of life is a highly effective method for prevention and control of hepatitis B.

Publication types

  • Review

MeSH terms

  • Hepatitis B / epidemiology*
  • Hepatitis B / immunology
  • Hepatitis B / prevention & control*
  • Hepatitis B Antibodies / blood
  • Hepatitis B Antibodies / immunology
  • Hepatitis B Vaccines / immunology
  • Hepatitis B Vaccines / therapeutic use
  • Hepatitis B virus / genetics
  • Hepatitis B virus / immunology
  • Humans
  • Vaccination


  • Hepatitis B Antibodies
  • Hepatitis B Vaccines