Hfq and its constellation of RNA

Nat Rev Microbiol. 2011 Aug 15;9(8):578-89. doi: 10.1038/nrmicro2615.


Hfq is an RNA-binding protein that is common to diverse bacterial lineages and has key roles in the control of gene expression. By facilitating the pairing of small RNAs with their target mRNAs, Hfq affects the translation and turnover rates of specific transcripts and contributes to complex post-transcriptional networks. These functions of Hfq can be attributed to its ring-like oligomeric architecture, which presents two non-equivalent binding surfaces that are capable of multiple interactions with RNA molecules. Distant homologues of Hfq occur in archaea and eukaryotes, reflecting an ancient origin for the protein family and hinting at shared functions. In this Review, we describe the salient structural and functional features of Hfq and discuss possible mechanisms by which this protein can promote RNA interactions to catalyse specific and rapid regulatory responses in vivo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacterial Proteins / chemistry
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Binding Sites
  • Gene Expression Regulation, Bacterial*
  • Host Factor 1 Protein / chemistry
  • Host Factor 1 Protein / genetics
  • Host Factor 1 Protein / metabolism*
  • Models, Biological
  • Models, Molecular
  • Protein Binding
  • Protein Biosynthesis*
  • Protein Multimerization
  • RNA, Messenger / metabolism
  • RNA, Untranslated / metabolism
  • RNA-Binding Proteins / chemistry
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism*


  • Bacterial Proteins
  • Host Factor 1 Protein
  • RNA, Messenger
  • RNA, Untranslated
  • RNA-Binding Proteins