Nuclear myocardial perfusion imaging with a novel cadmium-zinc-telluride detector SPECT/CT device: first validation versus invasive coronary angiography

Eur J Nucl Med Mol Imaging. 2011 Nov;38(11):2025-30. doi: 10.1007/s00259-011-1877-y. Epub 2011 Jul 15.


Purpose: We evaluated the diagnostic accuracy of attenuation corrected nuclear myocardial perfusion imaging (MPI) with a novel hybrid single photon emission computed tomography (SPECT)/CT device consisting of an ultrafast dedicated cardiac gamma camera with cadmium-zinc-telluride (CZT) solid-state semiconductor detectors integrated onto a multislice CT scanner to detect coronary artery disease (CAD). Invasive coronary angiography served as the standard of reference.

Methods: The study population included 66 patients (79% men; mean age 63 ± 11 years) who underwent 1-day (99m)Tc-tetrofosmin pharmacological stress/rest examination and angiography within 3 months. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) as well as accuracy of the CT X-ray based attenuation corrected CZT MPI for detection of CAD (≥ 50% luminal narrowing) was calculated on a per-patient basis.

Results: The prevalence of angiographic CAD in the study population was 82%. Sensitivity, specificity, PPV, NPV and accuracy were 87, 67, 92, 53 and 83%, respectively.

Conclusion: In this first report on CZT SPECT/CT MPI comparison versus angiography we confirm a high accuracy for detection of angiographically documented CAD.

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cadmium*
  • Coronary Angiography*
  • Coronary Artery Disease / diagnostic imaging
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Male
  • Middle Aged
  • Multimodal Imaging / instrumentation*
  • Multimodal Imaging / standards
  • Myocardial Perfusion Imaging / instrumentation*
  • Myocardial Perfusion Imaging / standards
  • Positron-Emission Tomography*
  • Reference Standards
  • Sensitivity and Specificity
  • Tellurium*
  • Tomography, X-Ray Computed*
  • Zinc*


  • CdZnTe
  • Cadmium
  • Zinc
  • Tellurium