Identification of the genetic origin of influenza A viruses will facilitate understanding of the genomic dynamics, evolutionary pathway, and viral fitness of influenza A viruses. The exponential increases of influenza sequences have expanded the coverage of influenza genetic pool, thus potentially reducing the biases for influenza progenitor identification. However, these large amounts of data generate a great challenge in progenitor identification. To increase computational efficiency, IPMiner is developed by integrating complete composition vector for genetic distance calculation and minimum spanning tree algorithm for progenitor identification. IPMiner is available to at