Impact of WNT signaling on tissue lineage differentiation in the early mouse embryo

Dev Growth Differ. 2011 Sep;53(7):843-56. doi: 10.1111/j.1440-169X.2011.01292.x. Epub 2011 Jul 15.

Abstract

WNT signaling activity is involved in the regulation of many cellular functions, including proliferation, migration, cell fate specification, maintenance of pluripotency and induction of tumorigenicity. Here we summarize recent progress towards understanding the regulation of canonical WNT/β-catenin signaling activity through feedback regulatory loops involving the ligands, agonists and antagonists, the availability of intracellular pools of active β-catenin and the cross-regulation of the WNT activity by β-catenin independent pathway. We also review recent findings on the role of WNT/β-catenin signaling in tissue lineage differentiation during embryogenesis and the maintenance and self renewal of embryo-derived stem cells in vitro.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Transcription Factors / genetics
  • Basic Helix-Loop-Helix Transcription Factors / metabolism
  • Cell Differentiation*
  • Cell Movement
  • Embryo, Mammalian / cytology*
  • Embryo, Mammalian / metabolism
  • Embryonic Development
  • Embryonic Stem Cells / cytology
  • Frizzled Receptors / genetics
  • Frizzled Receptors / metabolism
  • Gene Expression Regulation, Developmental*
  • Germ Layers / cytology
  • Germ Layers / embryology
  • Glypicans / metabolism
  • Heart / embryology
  • Heart / growth & development
  • Heparan Sulfate Proteoglycans / metabolism
  • Intercellular Signaling Peptides and Proteins / metabolism
  • Mice
  • Phenotype
  • SOXB1 Transcription Factors / genetics
  • SOXB1 Transcription Factors / metabolism
  • Wnt Proteins / agonists
  • Wnt Proteins / antagonists & inhibitors
  • Wnt Proteins / genetics
  • Wnt Proteins / metabolism*
  • Wnt Signaling Pathway*
  • beta Catenin / genetics
  • beta Catenin / metabolism

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • CTNNB1 protein, mouse
  • Dkk1 protein, mouse
  • Frizzled Receptors
  • Glypicans
  • Gpc4 protein, mouse
  • Gpc5 protein, mouse
  • Heparan Sulfate Proteoglycans
  • Intercellular Signaling Peptides and Proteins
  • SOXB1 Transcription Factors
  • Sox2 protein, mouse
  • Tcf3 protein, mouse
  • Wnt Proteins
  • beta Catenin