Skin cancer in solid organ transplant recipients: advances in therapy and management: part I. Epidemiology of skin cancer in solid organ transplant recipients

J Am Acad Dermatol. 2011 Aug;65(2):253-261. doi: 10.1016/j.jaad.2010.11.062.

Abstract

Skin cancer is the most frequent malignancy in organ transplant recipients, 95% of which are nonmelanoma skin cancer, especially squamous cell and basal cell carcinomas. This paper also discusses the incidence of other tumors (eg, melanoma, Merkel cell carcinoma, and Kaposi sarcoma) that are also increased in organ transplant patients compared to the general population. Part I of this two-part series describes the latest data concerning the epidemiologic and pathogenic aspects of nonmelanoma skin cancer development in solid organ transplant recipients. This review also highlights the concept of "field cancerization," represented by extensive areas of actinic damage and epidermal dysplasia, which accounts for increased risk of aggressive skin cancer development in susceptible patients.

Publication types

  • Review

MeSH terms

  • Carcinoma, Basal Cell / drug therapy
  • Carcinoma, Basal Cell / epidemiology
  • Carcinoma, Basal Cell / etiology
  • Carcinoma, Basal Cell / pathology
  • Carcinoma, Merkel Cell / drug therapy
  • Carcinoma, Merkel Cell / epidemiology
  • Carcinoma, Merkel Cell / etiology
  • Carcinoma, Merkel Cell / pathology
  • Carcinoma, Squamous Cell / drug therapy
  • Carcinoma, Squamous Cell / epidemiology
  • Carcinoma, Squamous Cell / etiology
  • Carcinoma, Squamous Cell / pathology
  • Education, Medical, Continuing
  • Female
  • Humans
  • Immunocompromised Host*
  • Incidence
  • Male
  • Melanoma / epidemiology
  • Melanoma / etiology
  • Melanoma / pathology
  • Organ Transplantation / adverse effects*
  • Organ Transplantation / methods
  • Prognosis
  • Pyrimidines / therapeutic use*
  • Risk Assessment
  • Sarcoma, Kaposi / drug therapy
  • Sarcoma, Kaposi / epidemiology
  • Sarcoma, Kaposi / etiology
  • Sarcoma, Kaposi / pathology
  • Sirolimus / therapeutic use*
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / epidemiology*
  • Skin Neoplasms / etiology
  • Skin Neoplasms / pathology
  • Survival Analysis
  • Treatment Outcome
  • Triazoles / therapeutic use*
  • Voriconazole

Substances

  • Pyrimidines
  • Triazoles
  • Voriconazole
  • Sirolimus