Manipulation of host membranes by bacterial effectors

Nat Rev Microbiol. 2011 Jul 18;9(9):635-46. doi: 10.1038/nrmicro2602.


Bacterial pathogens interact with host membranes to trigger a wide range of cellular processes during the course of infection. These processes include alterations to the dynamics between the plasma membrane and the actin cytoskeleton, and subversion of the membrane-associated pathways involved in vesicle trafficking. Such changes facilitate the entry and replication of the pathogen, and prevent its phagocytosis and degradation. In this Review, we describe the manipulation of host membranes by numerous bacterial effectors that target phosphoinositide metabolism, GTPase signalling and autophagy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autophagy
  • Bacteria / pathogenicity*
  • Bacterial Infections / microbiology*
  • Cell Membrane / metabolism
  • Cell Membrane / microbiology*
  • Host-Pathogen Interactions
  • Humans
  • Phosphatidylinositols / metabolism
  • Signal Transduction


  • Phosphatidylinositols