Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1990 Jul;87:245-54.
doi: 10.1289/ehp.9087245.

Mechanism of Action of Organophosphorus and Carbamate Insecticides

Affiliations
Free PMC article
Review

Mechanism of Action of Organophosphorus and Carbamate Insecticides

T R Fukuto. Environ Health Perspect. .
Free PMC article

Abstract

Organophosphorus and carbamate insecticides are toxic to insects and mammals by virtue of their ability to inactivate the enzyme acetylcholinesterase. This review addresses the mechanism of inhibition of acetylcholinesterase by organophosphorus and carbamate esters, focusing on structural requirements necessary for anticholinesterase activity. The inhibition of acetylcholinesterase by these compounds is discussed in terms of reactivity and steric effects. The role of metabolic activation or degradation in the overall intoxication process is also discussed.

Similar articles

See all similar articles

Cited by 121 articles

See all "Cited by" articles

References

    1. Biochem J. 1950 Apr;46(4):451-60 - PubMed
    1. Biochem J. 1952 Apr;51(1):62-70 - PubMed
    1. Biochim Biophys Acta. 1966 Sep 5;126(1):117-28 - PubMed
    1. J Biol Chem. 1987 Sep 25;262(27):13290-8 - PubMed
    1. Bull World Health Organ. 1971;44(1-3):43-78 - PubMed

LinkOut - more resources

Feedback