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. 1990 Jul;87:245-54.
doi: 10.1289/ehp.9087245.

Mechanism of Action of Organophosphorus and Carbamate Insecticides

Free PMC article

Mechanism of Action of Organophosphorus and Carbamate Insecticides

T R Fukuto. Environ Health Perspect. .
Free PMC article


Organophosphorus and carbamate insecticides are toxic to insects and mammals by virtue of their ability to inactivate the enzyme acetylcholinesterase. This review addresses the mechanism of inhibition of acetylcholinesterase by organophosphorus and carbamate esters, focusing on structural requirements necessary for anticholinesterase activity. The inhibition of acetylcholinesterase by these compounds is discussed in terms of reactivity and steric effects. The role of metabolic activation or degradation in the overall intoxication process is also discussed.

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