Brain Plasticity and Disease: A Matter of Inhibition

Neural Plast. 2011;2011:286073. doi: 10.1155/2011/286073. Epub 2011 Jul 3.

Abstract

One major goal in Neuroscience is the development of strategies promoting neural plasticity in the adult central nervous system, when functional recovery from brain disease and injury is limited. New evidence has underscored a pivotal role for cortical inhibitory circuitries in regulating plasticity both during development and in adulthood. This paper summarizes recent findings showing that the inhibition-excitation balance controls adult brain plasticity and is at the core of the pathogenesis of neurodevelopmental disorders like autism, Down syndrome, and Rett syndrome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autistic Disorder / physiopathology
  • Brain / physiology*
  • Down Syndrome / physiopathology
  • Humans
  • Neural Inhibition / physiology*
  • Neuronal Plasticity / physiology*
  • Neurons / physiology*
  • Rett Syndrome / physiopathology
  • gamma-Aminobutyric Acid / physiology*

Substances

  • gamma-Aminobutyric Acid