In vitro RBE-LET dependence for multiple particle types

Acta Oncol. 2011 Aug;50(6):757-62. doi: 10.3109/0284186X.2011.582518.


Background: In vitro RBE values for various high LET radiation types have been determined for many different cell types. Occasionally it is criticized that RBE for a given endpoint cannot be single-value dependent on LET alone, but also on particle species, due to the different dose deposition profiles on microscopic scale. Hence LET is not sufficient as a predictor of RBE, and this is one of the motivations for development of radiobiological models which explicitly depend on the detailed particle energy spectrum of the applied radiation field. The aim of the present study is to summarize the available data in the literature regarding the dependency of RBE on LET for different particles.

Method: As RBE is highly dependent on cell type and endpoint, we discriminated the RBE-LET relationship for the three investigated cell lines and at the same endpoint (10% survival in colony formation). Data points were collected from 20, four and four publications for V79, CHO and T1, respectively, in total covering 228 RBE values from a broad range of particle species.

Results and discussion: All RBE-LET data points demonstrate surprising agreement within the general error band formed by the numerous data points, and display the expected RBE peak at around 100-200 keV/μm. For all three cell lines, the influence of varying the particle type on the RBE was far from obvious, compared to the general experimental noise. Therefore, a dependence of particle type cannot be concluded, and LET alone in fact does seem to be an adequate parameter for describing RBE at 10% survival.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Linear Energy Transfer*
  • Neoplasms / radiotherapy*
  • Photons / therapeutic use*
  • Proton Therapy*
  • Relative Biological Effectiveness


  • Protons