Foxp3(+) Regulatory T Cell Expansion Required for Sustaining Pregnancy Compromises Host Defense Against Prenatal Bacterial Pathogens

Cell Host Microbe. 2011 Jul 21;10(1):54-64. doi: 10.1016/j.chom.2011.06.005.

Abstract

Although pregnancy confers unique susceptibility to infection, the pregnancy-associated immune defects that erode host defense remain largely undefined. Herein, we demonstrate that expansion of immune-suppressive Foxp3(+) regulatory T cells (Tregs) which occurs physiologically during pregnancy or when experimentally induced in transgenic mice caused enhanced susceptibility to prenatal pathogens including Listeria and Salmonella species. Reciprocally, infection susceptibility was uniformly reduced with Treg ablation. Importantly however, the sustained expansion of maternal Tregs was essential for maintaining immune tolerance to the developing fetus because even partial transient ablation of Foxp3-expressing cells fractured maternal tolerance to fetal antigen and triggered fetal resorption. Interestingly, Foxp3 cell-intrinsic defects in the immune-suppressive cytokine IL-10 alone were sufficient to override Treg-mediated infection susceptibility, while IL-10 was nonessential for sustaining pregnancy. Thus, maternal Treg expansion required for sustaining pregnancy creates naturally occurring holes in host defense that confer prenatal infection susceptibility.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Antigens / metabolism
  • Disease Susceptibility
  • Female
  • Fetus / immunology
  • Fetus / microbiology
  • Forkhead Transcription Factors / genetics
  • Forkhead Transcription Factors / metabolism*
  • Host-Pathogen Interactions*
  • Interleukin-10 / immunology*
  • Interleukin-10 / metabolism
  • Listeria / immunology
  • Listeria / pathogenicity
  • Mice
  • Mice, Transgenic
  • Pregnancy / immunology*
  • Pregnancy Complications, Infectious / immunology*
  • Pregnancy Complications, Infectious / metabolism
  • Pregnancy Complications, Infectious / microbiology
  • Salmonella / immunology
  • Salmonella / pathogenicity
  • T-Lymphocytes, Regulatory / physiology*

Substances

  • Antigens
  • Forkhead Transcription Factors
  • Foxp3 protein, mouse
  • IL10 protein, mouse
  • Interleukin-10