Foreign-body granuloma after injection of calcium hydroxylapatite for type III stress urinary incontinence

Obstet Gynecol. 2011 Aug;118(2 Pt 2):418-21. doi: 10.1097/AOG.0b013e3182161953.

Abstract

Background: Foreign-body granuloma is a potential complication of periurethral injection of calcium hydroxylapatite for the treatment of type III stress urinary incontinence.

Cases: We present two cases of foreign-body granuloma formation after periurethral injection of calcium hydroxylapatite for type III stress urinary incontinence. Excision of the lesion resulted in cessation of pain in a symptomatic patient; however, it led to the resumption of stress urinary incontinence in both cases.

Conclusion: Foreign-body granuloma is not the normative response to periurethral bulking with calcium hydroxylapatite. However, granuloma should be considered when a periurethral mass is encountered after injection of calcium hydroxylapatite for type III stress urinary incontinence.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biocompatible Materials / adverse effects*
  • Biocompatible Materials / therapeutic use
  • Durapatite / adverse effects*
  • Durapatite / therapeutic use
  • Female
  • Granuloma, Foreign-Body / chemically induced
  • Granuloma, Foreign-Body / diagnosis*
  • Granuloma, Foreign-Body / pathology
  • Granuloma, Foreign-Body / surgery
  • Humans
  • Middle Aged
  • Pain / surgery
  • Recurrence
  • Treatment Outcome
  • Urinary Incontinence, Stress / drug therapy*

Substances

  • Biocompatible Materials
  • Durapatite