Relationship of low plasma klotho with poor grip strength in older community-dwelling adults: the InCHIANTI study

Eur J Appl Physiol. 2012 Apr;112(4):1215-20. doi: 10.1007/s00421-011-2072-3. Epub 2011 Jul 17.

Abstract

Handgrip strength is a strong indicator of total body muscle strength and is a predictor of poor outcomes in older adults. The aging suppressor gene klotho encodes a single-pass transmembrane protein that is secreted as a circulating hormone. In mice, disruption of klotho expression results in a syndrome that includes sarcopenia, atherosclerosis, osteoporosis, and shortened lifespan, and conversely, overexpression of klotho leads to a greater longevity. The objective was to determine whether plasma klotho levels are related to skeletal muscle strength in humans. We measured plasma klotho in 804 adults, ≥65 years, in the InCHIANTI study, a longitudinal population-based study of aging in Tuscany, Italy. Grip strength was positively correlated with plasma klotho at threshold <681 pg/mL. After adjusting for age, sex, education, smoking, physical activity, cognition, and chronic diseases, plasma klotho (per 1 standard deviation increase) was associated with grip strength (beta = 1.20, standard error = 0.35, P = 0.0009) in adults with plasma klotho <681 pg/mL. These results suggest that older adults with lower plasma klotho have poor skeletal muscle strength.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging / blood*
  • Biomarkers / blood
  • Down-Regulation
  • Female
  • Glucuronidase / blood*
  • Hand Strength*
  • Humans
  • Independent Living*
  • Italy / epidemiology
  • Linear Models
  • Longitudinal Studies
  • Male
  • Multivariate Analysis
  • Muscle Strength Dynamometer
  • Muscle, Skeletal / physiopathology*
  • Risk Assessment
  • Risk Factors
  • Sarcopenia / blood*
  • Sarcopenia / epidemiology
  • Sarcopenia / physiopathology*

Substances

  • Biomarkers
  • Glucuronidase
  • klotho protein