Abstract
Purpose:
To report a case of cytomegalovirus (CMV) endotheliitis after insertion of an intravitreal fluocinolone acetonide (Retisert) implant.
Design:
Interventional case report.
Methods:
Retrospective chart review.
Results:
A 40-year-old man received a Retisert implant in the left eye for recurrent Behçet uveitis. Although inflammation became quiescent within a month, corneal edema developed 4 months after insertion. Polymerase chain reaction analysis for aqueous humor detected 3.9 × 10(4) copies/mL of CMV DNA. After treatment with oral valganciclovir, CMV DNA nearly disappeared but visual outcome was poor due to corneal decompensation resulting from severe endothelial cell loss.
Conclusions:
After Retisert implant, clinicians should be attentive to the potential risk of CMV endotheliitis.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Adult
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Anti-Inflammatory Agents / administration & dosage*
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Antiviral Agents / administration & dosage
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Behcet Syndrome / complications*
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Corneal Edema / complications
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Corneal Edema / drug therapy
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Corneal Edema / virology
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Cytomegalovirus Infections / complications*
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Cytomegalovirus Infections / drug therapy
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Drug Implants / adverse effects
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Endothelium, Corneal / virology*
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Fluocinolone Acetonide / administration & dosage*
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Ganciclovir / administration & dosage
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Ganciclovir / analogs & derivatives
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Humans
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Inflammation / complications
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Inflammation / drug therapy
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Inflammation / virology*
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Male
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Uveitis / drug therapy*
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Uveitis / etiology
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Valganciclovir
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Vision Disorders / etiology
Substances
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Anti-Inflammatory Agents
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Antiviral Agents
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Drug Implants
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Fluocinolone Acetonide
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Valganciclovir
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Ganciclovir