Serum Selenium Concentration at Diagnosis and Outcome in Patients With Haematological Malignancies

Br J Haematol. 2011 Aug;154(4):448-56. doi: 10.1111/j.1365-2141.2011.08744.x. Epub 2011 Jul 20.

Abstract

We have previously reported presentation serum selenium level to be predictive of outcome in diffuse large B-cell lymphoma. This has now been studied in a further 430 patients, 163 with acute myeloid leukaemia (AML), 156 with Hodgkin Lymphoma (HL), and 111 with Follicular Lymphoma (FL). Serum selenium was below the UK normal reference range in 45% of patients, and correlated with serum albumin (r=0·24-0·46, P<0·001-0·003) in all tumour types. Independent predictors of presentation selenium were; French-American-British subtype and albumin (P<0·001 for both) in AML, haemoglobin (P=0·002) and B-symptoms (P=0·01) in HL, and albumin (P<0·001) in FL. In AML and HL, response to first line therapy was lower in patients with low serum selenium, but selenium was no longer predictive of response when other variables were entered into a multivariate model. Low selenium was also associated with a worse overall survival in FL [Hazard Ratio (HR) 2·3, 95% confidence interval (CI) 1·4, 4·0] and a trend to a worse overall survival in AML (HR 1·43, 95% CI 0·96, 2·13) by univariate Cox regression analysis, but not by multivariate analysis. In conclusion, low serum selenium is associated with a worse outcome in patients with haematological malignancies, but is not independently predictive, suggesting that it reflects other factors.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / blood*
  • Female
  • Follow-Up Studies
  • Hematologic Neoplasms / blood
  • Hematologic Neoplasms / diagnosis*
  • Hematologic Neoplasms / therapy
  • Hodgkin Disease / blood
  • Hodgkin Disease / diagnosis
  • Hodgkin Disease / therapy
  • Humans
  • Kaplan-Meier Estimate
  • Leukemia, Myeloid, Acute / blood
  • Leukemia, Myeloid, Acute / diagnosis
  • Leukemia, Myeloid, Acute / therapy
  • Lymphoma, Follicular / blood
  • Lymphoma, Follicular / diagnosis
  • Lymphoma, Follicular / therapy
  • Male
  • Middle Aged
  • Prognosis
  • Selenium / blood*
  • Serum Albumin / metabolism
  • Treatment Outcome
  • Young Adult

Substances

  • Biomarkers, Tumor
  • Serum Albumin
  • Selenium