Developmental regulation of CYCA2s contributes to tissue-specific proliferation in Arabidopsis

EMBO J. 2011 Jul 19;30(16):3430-41. doi: 10.1038/emboj.2011.240.


In multicellular organisms, morphogenesis relies on a strict coordination in time and space of cell proliferation and differentiation. In contrast to animals, plant development displays continuous organ formation and adaptive growth responses during their lifespan relying on a tight coordination of cell proliferation. How developmental signals interact with the plant cell-cycle machinery is largely unknown. Here, we characterize plant A2-type cyclins, a small gene family of mitotic cyclins, and show how they contribute to the fine-tuning of local proliferation during plant development. Moreover, the timely repression of CYCA2;3 expression in newly formed guard cells is shown to require the stomatal transcription factors FOUR LIPS/MYB124 and MYB88, providing a direct link between developmental programming and cell-cycle exit in plants. Thus, transcriptional downregulation of CYCA2s represents a critical mechanism to coordinate proliferation during plant development.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Arabidopsis / cytology*
  • Arabidopsis / genetics
  • Arabidopsis Proteins / biosynthesis
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / physiology*
  • Cell Cycle
  • Cell Division
  • Cyclin A2 / biosynthesis
  • Cyclin A2 / genetics
  • Cyclin A2 / physiology*
  • Down-Regulation
  • Gene Expression Regulation, Developmental*
  • Gene Expression Regulation, Plant*
  • Morphogenesis
  • Organ Specificity
  • Plant Leaves / metabolism
  • Plant Roots / metabolism
  • Polyploidy
  • Transcription Factors / physiology


  • Arabidopsis Proteins
  • Cyclin A2
  • FLP protein, Arabidopsis
  • Myb88 protein, Arabidopsis
  • Transcription Factors
  • cyclin A2;3 protein, Arabidopsis