Return to homeostasis: downregulation of NF-κB responses

Nat Immunol. 2011 Jun 19;12(8):709-14. doi: 10.1038/ni.2055.


Activation of NF-κB transcription factors by receptors of the innate or adaptive immune system is essential for host defense. However, after danger is eliminated, NF-κB signaling needs to be tightly downregulated for the maintenance of tissue homeostasis. This review highlights key negative regulatory principles that affect the amount, localization or conformational properties of NF-κB-activating proteins to attenuate the NF-κB response. These mechanisms are needed to prevent inflammation, autoimmune disease and oncogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Down-Regulation / immunology
  • Feedback
  • Homeostasis / immunology
  • Humans
  • NF-kappa B / antagonists & inhibitors
  • NF-kappa B / immunology*
  • Signal Transduction / immunology
  • Transcription, Genetic / immunology
  • Transcriptional Activation / immunology


  • NF-kappa B