Reoxygenation injury and antioxidant protection: a tale of two paradoxes

J M Gutteridge; B Halliwell

doi:10.1016/0003-9861(90)90635-c

Reoxygenation injury and antioxidant protection: a tale of two paradoxes

Arch Biochem Biophys. 1990 Dec;283(2):223-6. doi: 10.1016/0003-9861(90)90635-c.

Authors

J M Gutteridge¹, B Halliwell

Affiliation

¹ Molecular Toxicology, Oklahoma Medical Research Foundation, Oklahoma City 73104.

PMID: 2177320
DOI: 10.1016/0003-9861(90)90635-c

Abstract

Under certain circumstances, added antioxidants can protect tissues against reoxygenation injury after ischemia. Yet reperfusing blood carries many antioxidants with it. The implications of this "antioxidant paradox" are discussed.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antioxidants / metabolism*
Antioxidants / therapeutic use
Humans
Models, Biological
Reperfusion Injury / drug therapy*
Superoxides / metabolism

Substances

Antioxidants
Superoxides