Comparative healing property of kombucha tea and black tea against indomethacin-induced gastric ulceration in mice: possible mechanism of action

Food Funct. 2010 Dec;1(3):284-93. doi: 10.1039/c0fo00025f. Epub 2010 Nov 3.


The healing activity of black tea (BT) and BT fermented with Candida parapsilosis and kombucha culture, designated as CT and KT respectively against the indomethacin-induced stomach ulceration has been studied in a mouse model. The KT sample (KT4) produced by fermenting BT for four days, showed the best DPPH radical scavenging capacity and phenolics contents. Hence the ulcer-healing activity of KT4 was compared with those of CT4 and BT. All the tea extracts (15 mg kg(-1)) could effectively heal the gastric ulceration as revealed from the histopathological and biochemical studies, with relative efficacy as KT4 > CT4 ∼ BT. The healing capacities of the tea extracts could be attributed to their antioxidant activity as well as the ability to protect the mucin content of the gastric tissues. In addition, the ability of KT4 to reduce gastric acid secretion might also contribute to its ulcer-healing activity. The tea preparation KT4 (15 mg kg(-1)) was as effective as the positive control, omeprazole (3 mg kg(-1)) in ulcer healing.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / toxicity
  • Anti-Ulcer Agents / pharmacology
  • Disease Models, Animal
  • Fermentation
  • Free Radical Scavengers / pharmacology
  • Gastric Mucins / metabolism
  • Gastric Mucosa / metabolism
  • Indomethacin / toxicity*
  • Male
  • Mice
  • Omeprazole / pharmacology
  • Oxidative Stress / drug effects
  • Plant Extracts / pharmacology*
  • Stomach / drug effects
  • Stomach / pathology
  • Stomach Ulcer / chemically induced*
  • Stomach Ulcer / drug therapy*
  • Stomach Ulcer / pathology
  • Tea / chemistry*
  • Tea / metabolism
  • Thiobarbituric Acid Reactive Substances / metabolism
  • Wound Healing / drug effects*


  • Anti-Inflammatory Agents, Non-Steroidal
  • Anti-Ulcer Agents
  • Free Radical Scavengers
  • Gastric Mucins
  • Plant Extracts
  • Tea
  • Thiobarbituric Acid Reactive Substances
  • Omeprazole
  • Indomethacin