Stable aluminium fluoride chelates with triazacyclononane derivatives proved by X-ray crystallography and 18F-labeling study

Dinesh Shetty; Soo Young Choi; Jae Min Jeong; Ji Youn Lee; Lathika Hoigebazar; Yun-Sang Lee; Dong Soo Lee; June-Key Chung; Myung Chul Lee; Young Keun Chung

doi:10.1039/c1cc13151f

Stable aluminium fluoride chelates with triazacyclononane derivatives proved by X-ray crystallography and 18F-labeling study

Chem Commun (Camb). 2011 Sep 14;47(34):9732-4. doi: 10.1039/c1cc13151f. Epub 2011 Jul 21.

Authors

Dinesh Shetty¹, Soo Young Choi, Jae Min Jeong, Ji Youn Lee, Lathika Hoigebazar, Yun-Sang Lee, Dong Soo Lee, June-Key Chung, Myung Chul Lee, Young Keun Chung

Affiliation

¹ Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Korea.

PMID: 21776539
DOI: 10.1039/c1cc13151f

Abstract

A single crystal structure of an aluminium-fluoride complex of a model compound (NODA-benzyl) was studied to understand the co-ordination chemistry. Series of ligands with an extra carboxylic acid linker for biomolecule conjugation were studied for improved (18)F-labeling applications.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetates / chemistry
Aluminum Compounds / chemistry*
Animals
Aza Compounds / chemistry*
Aza Compounds / pharmacokinetics
Chelating Agents / chemistry*
Chelating Agents / pharmacokinetics
Crystallography, X-Ray
Fluorides / chemistry*
Fluorine Radioisotopes / chemistry*
Isotope Labeling / methods*
Mice
Models, Molecular
Molecular Conformation
Piperidines / chemistry*
Piperidines / pharmacokinetics

Substances

Acetates
Aluminum Compounds
Aza Compounds
Chelating Agents
Fluorine Radioisotopes
Piperidines
triazacyclononane
Fluorides
aluminum fluoride