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. 2011 Aug 31;133(34):13232-5.
doi: 10.1021/ja204249p. Epub 2011 Aug 9.

ESI-MS Assay of M. Tuberculosis Cell Wall Antigen 85 Enzymes Permits Substrate Profiling and Design of a Mechanism-Based Inhibitor

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ESI-MS Assay of M. Tuberculosis Cell Wall Antigen 85 Enzymes Permits Substrate Profiling and Design of a Mechanism-Based Inhibitor

Conor S Barry et al. J Am Chem Soc. .

Abstract

Mycobacterium tuberculosis Antigen 85 enzymes are vital to the integrity of the highly impermeable cell envelope and are potential therapeutic targets. Kinetic analysis using a label-free assay revealed both mechanistic details and a substrate profile that allowed the design and construction of a selective in vitro mechanism-based inhibitor.

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