The 'Invisible Hand': Regulation of RHO GTPases by RHOGDIs

Nat Rev Mol Cell Biol. 2011 Jul 22;12(8):493-504. doi: 10.1038/nrm3153.

Abstract

The 'invisible hand' is a term originally coined by Adam Smith in The Theory of Moral Sentiments to describe the forces of self-interest, competition and supply and demand that regulate the resources in society. This metaphor continues to be used by economists to describe the self-regulating nature of a market economy. The same metaphor can be used to describe the RHO-specific guanine nucleotide dissociation inhibitor (RHOGDI) family, which operates in the background, as an invisible hand, using similar forces to regulate the RHO GTPase cycle.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Evolution, Molecular
  • Guanine Nucleotide Dissociation Inhibitors / chemistry
  • Guanine Nucleotide Dissociation Inhibitors / genetics
  • Guanine Nucleotide Dissociation Inhibitors / metabolism*
  • Humans
  • Membrane Microdomains / metabolism
  • Metabolic Networks and Pathways
  • Models, Biological
  • Models, Molecular
  • Molecular Chaperones / metabolism
  • Multiprotein Complexes
  • Neoplasms / metabolism
  • Phosphorylation
  • Phylogeny
  • Protein Interaction Domains and Motifs
  • rho GTP-Binding Proteins / chemistry
  • rho GTP-Binding Proteins / metabolism*
  • rho Guanine Nucleotide Dissociation Inhibitor alpha
  • rho-Specific Guanine Nucleotide Dissociation Inhibitors

Substances

  • ARHGDIA protein, human
  • Guanine Nucleotide Dissociation Inhibitors
  • Molecular Chaperones
  • Multiprotein Complexes
  • rho Guanine Nucleotide Dissociation Inhibitor alpha
  • rho-Specific Guanine Nucleotide Dissociation Inhibitors
  • rho GTP-Binding Proteins