Why are multi-centre clinical observational studies still so difficult to run?

Br Dent J. 2011 Jul 22;211(2):59-61. doi: 10.1038/sj.bdj.2011.570.


Despite the introduction of IRAS, obtaining R&D approvals for multicentre studies is a major rate limiting step. Our experience with cleft research demonstrates that this approvals process must be drastically and rapidly improved if we wish to continue attract clinical research to the UK.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cleft Lip / therapy
  • Cleft Palate / therapy
  • Clinical Governance
  • Clinical Trials as Topic*
  • Contracts
  • Dental Research*
  • Ethics, Research
  • Forms and Records Control
  • Head and Neck Neoplasms / therapy
  • Humans
  • Multicenter Studies as Topic*
  • Online Systems
  • Outcome and Process Assessment, Health Care
  • Patient Care Team
  • Research Design*
  • Research Personnel
  • Research Support as Topic
  • State Dentistry
  • Time Factors
  • United Kingdom