Myc: the beauty and the beast

Genes Cancer. 2010 Jun;1(6):532-41. doi: 10.1177/1947601910378024.


The iconic history of the Myc oncoprotein encompasses 3 decades of intense scientific discovery. There is no question that Myc has been a pioneer, advancing insight into the molecular basis of cancer as well as functioning as a critical control center for several diverse biological processes and regulatory mechanisms. This narrative chronicles the journey and milestones that have defined the understanding of Myc, and it provides an opportunity to consider future directions in this challenging yet rewarding field.

Keywords: Myc; cancer; cell cycle; oncogene; transcription.