Correlation between crossed cerebellar diaschisis and clinical neurological scales

Acta Neurol Scand. 2012 Jun;125(6):373-81. doi: 10.1111/j.1600-0404.2011.01576.x. Epub 2011 Jul 23.


Background: A common consequence of unilateral stroke is crossed cerebellar diaschisis (CCD), a decrease in regional blood flow (CBF) and metabolism (CMRglu) in the cerebellar hemisphere contralateral to the affected cerebral hemisphere. Former studies indicated a post-stroke time-dependent relationship between the degree of CCD and the clinical status of acute and sub-acute stroke patients, but no study has been performed in post-stroke patients.

Objectives: The objective of this investigation was to evaluate the quantitative correlation between the degree of CCD and the values of clinical stroke scales in post-stroke patients.

Materials and methods: We measured with positron emission tomography (PET) regional CBF and CMRglu values in the affected cortical regions and the contralateral cerebellum in ten ischaemic post-stroke patients. Based on these quantitative parameters, the degree of diaschisis (DoD) was calculated, and the DoD values were correlated with three clinical stroke scales [Barthel Index, Orgogozo Scale and Scandinavian Neurological Scale (SNS)].

Results: There were significant linear correlations between all clinical stroke scales and the CCD values (Barthel Index and Orgogozo Scale: P < 0.001, for both CBF and CMRglu; SNS: P = 0.007 and P = 0.044; CBF and CMRglu, respectively).

Conclusions: The findings indicate that DoD can be used as a quantitative indicator of the functional impairments following stroke, i.e. it can serve as a potential surrogate of the severity of the damage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Brain Ischemia / diagnostic imaging
  • Brain Ischemia / etiology
  • Brain Ischemia / metabolism
  • Brain Ischemia / physiopathology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Positron-Emission Tomography
  • Regional Blood Flow
  • Registries
  • Severity of Illness Index*
  • Stroke / complications
  • Stroke / diagnostic imaging
  • Stroke / metabolism
  • Stroke / physiopathology*