Nanoscale studies of protein-membrane interactions in blood clotting

J Thromb Haemost. 2011 Jul;9 Suppl 1(Suppl 1):162-7. doi: 10.1111/j.1538-7836.2011.04300.x.


Most of the steps in the blood clotting cascade require clotting proteins to bind to membrane surfaces with exposed phosphatidylserine. In spite of the importance of these protein-membrane interactions, we still lack a detailed understanding of how clotting proteins interact with membranes and how membranes contribute so profoundly to catalysis. Our laboratories are using multidisciplinary approaches to explore, at atomic-resolution, how blood clotting protein complexes assemble and function on membrane surfaces.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Blood Coagulation*
  • Cell Membrane / metabolism*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Molecular Dynamics Simulation
  • Nanotechnology*
  • Proteins / metabolism*


  • Proteins