Cinnamon extract ameliorates ionizing radiation-induced cellular injury in rats

Ecotoxicol Environ Saf. 2011 Nov;74(8):2324-9. doi: 10.1016/j.ecoenv.2011.06.016. Epub 2011 Jul 22.


The present study aimed to investigate the protective role of cinnamon extract against inflammatory and oxidative injuries in gamma irradiated rats. Rats were subjected to fractionated doses of gamma radiation. Cinnamon extract were daily administrated before starting irradiation and continued after radiation exposure. The results obtained revealed that the administration of cinnamon extract to irradiated rats significantly ameliorated the changes induced in liver antioxidant system; catalase, superoxide dismutase and glutathione peroxidase activities as well as reduced glutathione concentration. The liver's lipid peroxidation and protein oxidation indices were significantly decreased when compared with their equivalent values in irradiated rats. Furthermore, the changes induces in xanthine oxidoreductase system were significantly diminished. In addition, the changes in liver nitric oxide contents, serum tumor necrosis factor alpha and C-reactive protein levels were markedly improved. In conclusion, the administration of cinnamon extract might provide substantial protection against radiation-induced oxidative and inflammatory damages.

MeSH terms

  • Animals
  • Catalase / metabolism
  • Cinnamomum zeylanicum*
  • Gamma Rays
  • Glutathione / metabolism
  • Glutathione Peroxidase / metabolism
  • Lipid Peroxidation / drug effects
  • Lipid Peroxidation / radiation effects
  • Liver / metabolism
  • Liver / pathology
  • Liver / radiation effects*
  • Male
  • Oxidation-Reduction
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Radiation Injuries, Experimental / drug therapy
  • Radiation Injuries, Experimental / metabolism
  • Radiation Injuries, Experimental / pathology
  • Radiation-Protective Agents / pharmacology*
  • Radiation-Protective Agents / therapeutic use
  • Rats
  • Rats, Wistar
  • Superoxide Dismutase / metabolism
  • Thiobarbituric Acid Reactive Substances / metabolism


  • Plant Extracts
  • Radiation-Protective Agents
  • Thiobarbituric Acid Reactive Substances
  • Catalase
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Glutathione