Presence and impact of the exercise-induced collapse associated DNM1 mutation in Labrador retrievers and other breeds

Vet J. 2011 Aug;189(2):214-9. doi: 10.1016/j.tvjl.2011.06.022. Epub 2011 Jul 22.


The impact of the mutation causing dynamin 1 (DNM1)-associated exercise-induced collapse (d-EIC) was determined in a retrospective genetic survey. The frequency of DNM1 mutant allele carriers in Labrador retrievers from conformation show, field trial/hunt test, pet or service lines ranged from 17.9% to 38.0% and the frequency of homozygous mutant (EE genotype) individuals ranged from 1.8% to 13.6%; 83.6% of these EE Labradors were reported to have collapsed by 4 years of age. DNM1 mutation carriers and EE dogs with a collapse phenotype were also detected in Chesapeake Bay retrievers, Curly-coated retrievers, Boykin spaniels, Pembroke Welsh corgis and mixed breed dogs thought to be Labrador retriever crosses. The DNM1 mutation was not identified in Golden, Flat-coated, or Nova Scotia duck tolling retrievers, or 15 other non-retrieving breeds. Veterinarians and breeders should be aware that the DNM1 EE genotype is not completely penetrant and that d-EIC is a widespread health concern in several very popular breeds, as well as breeds whose genetic similarity to retrievers is not obvious.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Canada / epidemiology
  • Dog Diseases / epidemiology
  • Dog Diseases / genetics*
  • Dog Diseases / pathology
  • Dogs
  • Dynamin I / genetics*
  • Gene Frequency
  • Muscle Weakness / epidemiology
  • Muscle Weakness / genetics
  • Muscle Weakness / physiopathology
  • Muscle Weakness / veterinary*
  • Mutation*
  • Pedigree
  • Phenotype
  • Physical Conditioning, Animal / adverse effects*
  • Retrospective Studies
  • Species Specificity
  • United States / epidemiology


  • Dynamin I