Cell division: aurora B illuminates a checkpoint pathway

Curr Biol. 2011 Jul 26;21(14):R557-9. doi: 10.1016/j.cub.2011.06.020.

Abstract

Separating mitotic error correction, chromosome biorientation and the spindle assembly checkpoint (SAC) is complicated by their interconnected relationships. New research finds that Aurora B kinase, which drives error correction and promotes biorientation, also directly regulates the SAC.

MeSH terms

  • Aurora Kinase B
  • Aurora Kinases
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism*
  • Cell Line
  • Chromosome Segregation
  • Humans
  • Kinetochores / physiology*
  • Microtubules / drug effects
  • Mitosis*
  • Nocodazole / pharmacology
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism*
  • Signal Transduction*
  • Spindle Apparatus / physiology*
  • Tubulin Modulators / pharmacology

Substances

  • Cell Cycle Proteins
  • Tubulin Modulators
  • AURKB protein, human
  • Aurora Kinase B
  • Aurora Kinases
  • Protein-Serine-Threonine Kinases
  • Nocodazole