Abstract
One new phenanthrenedione, pterolinus K (1), and one new chalcone, pterolinus L (2) were isolated from the heartwood extract of Pterocarpus santalinus. The structures were elucidated by spectroscopic methods. Both 1 and 2 showed inhibitory effect on elastase release by human neutrophils in response to fMLP with an IC(50) value of 4.24 and 0.95 μM, and compound 1 also inhibited superoxide anion generation with IC(50) value of 0.99 μM. In addition, compound 1 showed selective cytotoxicity against HepG2 with IC(50) value of 10.86 μM, while compound 2 showed a moderate cytotoxicity against KB with IC(50) values of 17.18 μM.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Cell Proliferation / drug effects
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Chalcones / chemistry
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Chalcones / isolation & purification
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Chalcones / pharmacology*
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Hep G2 Cells
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Humans
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KB Cells
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Molecular Structure
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N-Formylmethionine Leucyl-Phenylalanine / pharmacology
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Neutrophils / enzymology
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Pancreatic Elastase / antagonists & inhibitors*
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Pancreatic Elastase / metabolism
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Phenanthrenes / chemistry
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Phenanthrenes / isolation & purification
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Phenanthrenes / pharmacology*
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Pterocarpus / chemistry*
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Stereoisomerism
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Structure-Activity Relationship
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Superoxides / antagonists & inhibitors
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Superoxides / metabolism
Substances
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Antineoplastic Agents
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Chalcones
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Enzyme Inhibitors
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Phenanthrenes
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Plant Extracts
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pterolinus K
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pterolinus L
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Superoxides
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N-Formylmethionine Leucyl-Phenylalanine
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Pancreatic Elastase