Production of 2-hydroxyglutarate by isocitrate dehydrogenase 1-mutated gliomas: an evolutionary alternative to the Warburg shift?

Neuro Oncol. 2011 Dec;13(12):1262-4. doi: 10.1093/neuonc/nor083. Epub 2011 Jul 22.
No abstract available

Publication types

  • Letter

MeSH terms

  • Brain Neoplasms / genetics*
  • Brain Neoplasms / metabolism
  • Evolution, Molecular*
  • Glioma / genetics*
  • Glioma / metabolism
  • Glutarates / metabolism*
  • Glycolysis
  • Humans
  • Isocitrate Dehydrogenase / genetics*
  • Mutation / genetics*
  • Oxygen Consumption / physiology*

Substances

  • Glutarates
  • alpha-hydroxyglutarate
  • Isocitrate Dehydrogenase
  • IDH1 protein, human