Intra-amygdala ZIP injections impair the memory of learned active avoidance responses and attenuate conditioned taste-aversion acquisition in rats

Learn Mem. 2011 Jul 22;18(8):529-33. doi: 10.1101/lm.2253311. Print 2011 Aug.

Abstract

We have investigated the effect of protein kinase Mzeta (PKMζ) inhibition in the basolateral amygdala (BLA) upon the retention of a nonspatial learned active avoidance response and conditioned taste-aversion (CTA) acquisition in rats. ZIP (10 nmol/μL) injected into the BLA 24 h after training impaired retention of a learned avoidance-jumping response assessed 7 d later when compared with control groups injected with scrambled-ZIP. Nevertheless, a retraining session applied 24 h later indicated no differences between the groups. Additionally, a similar ZIP injection into the BLA during the conditioned stimulus-unconditioned stimulus (CS-US) interval attenuated CTA acquisition. These findings support the BLA PKMζ role in various forms of memory.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amygdala / drug effects*
  • Amygdala / physiology
  • Animals
  • Avoidance Learning / drug effects
  • Cell-Penetrating Peptides
  • Conditioning, Classical / drug effects
  • Conditioning, Operant / drug effects
  • Conditioning, Psychological / drug effects*
  • Disease Models, Animal
  • Drug Administration Routes
  • Food Preferences / drug effects
  • Lipopeptides / pharmacology
  • Male
  • Memory Disorders / chemically induced*
  • Oligopeptides / pharmacology*
  • Protein Kinase C / antagonists & inhibitors*
  • Protein Kinase C / chemistry
  • Rats
  • Rats, Wistar
  • Saccharin / administration & dosage
  • Taste / drug effects*

Substances

  • Cell-Penetrating Peptides
  • Lipopeptides
  • Oligopeptides
  • zeta-inhibitory peptide
  • Protein Kinase C
  • protein kinase M zeta, rat
  • Saccharin