Abstract
We have investigated the effect of protein kinase Mzeta (PKMζ) inhibition in the basolateral amygdala (BLA) upon the retention of a nonspatial learned active avoidance response and conditioned taste-aversion (CTA) acquisition in rats. ZIP (10 nmol/μL) injected into the BLA 24 h after training impaired retention of a learned avoidance-jumping response assessed 7 d later when compared with control groups injected with scrambled-ZIP. Nevertheless, a retraining session applied 24 h later indicated no differences between the groups. Additionally, a similar ZIP injection into the BLA during the conditioned stimulus-unconditioned stimulus (CS-US) interval attenuated CTA acquisition. These findings support the BLA PKMζ role in various forms of memory.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amygdala / drug effects*
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Amygdala / physiology
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Animals
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Avoidance Learning / drug effects
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Cell-Penetrating Peptides
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Conditioning, Classical / drug effects
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Conditioning, Operant / drug effects
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Conditioning, Psychological / drug effects*
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Disease Models, Animal
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Drug Administration Routes
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Food Preferences / drug effects
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Lipopeptides / pharmacology
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Male
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Memory Disorders / chemically induced*
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Oligopeptides / pharmacology*
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Protein Kinase C / antagonists & inhibitors*
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Protein Kinase C / chemistry
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Rats
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Rats, Wistar
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Saccharin / administration & dosage
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Taste / drug effects*
Substances
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Cell-Penetrating Peptides
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Lipopeptides
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Oligopeptides
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zeta-inhibitory peptide
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Protein Kinase C
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protein kinase M zeta, rat
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Saccharin