Use of topical corticosteroids in the treatment of childhood asthma

Am Rev Respir Dis. 1990 Feb;141(2 Pt 2):S77-81.


Various aspects of topical corticosteroids in the treatment of childhood asthma are reviewed: indications, application and bioavailability, dosing schedules, clinical efficacy, effects on non-specific bronchial hyperresponsiveness, bronchial reactions after allergen challenge, and exercise-induced bronchoconstriction, as well as possible side effects such as the influences on the hypothalamic-pituitary-adrenal axis or growth and other potentially harmful actions. It was concluded that topical corticosteroids are very beneficial in the treatment of moderate-to-severe childhood asthma and that the risk of side effects can be neglected when the required doses for most patients are used.

Publication types

  • Review

MeSH terms

  • Administration, Inhalation
  • Administration, Topical
  • Anti-Inflammatory Agents / adverse effects
  • Anti-Inflammatory Agents / pharmacokinetics
  • Anti-Inflammatory Agents / therapeutic use*
  • Asthma / drug therapy*
  • Asthma / physiopathology
  • Biological Availability
  • Child
  • Child, Preschool
  • Drug Administration Schedule
  • Glucocorticoids
  • Humans
  • Infant


  • Anti-Inflammatory Agents
  • Glucocorticoids