TFEB Regulates Autophagy: An Integrated Coordination of Cellular Degradation and Recycling Processes

Autophagy. 2011 Nov;7(11):1379-81. doi: 10.4161/auto.7.11.17166. Epub 2011 Nov 1.

Abstract

Autophagy is a fundamental catabolic process that plays a central role in health and disease. An efficient autophagic process relies on the cooperation of two distinct types of organelles: the autophagosome and the lysosome. We have identified a gene network that regulates the biogenesis and function of both organelles. Our findings reveal an important role of transcription in the regulation of starvation-induced autophagy, and link lysosomal biogenesis to autophagy.

MeSH terms

  • Animals
  • Autophagy / genetics*
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / metabolism*
  • Gene Regulatory Networks / genetics*
  • Lysosomes / metabolism
  • Mice
  • Models, Biological

Substances

  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors