[The association of Serenoa repens, lycopene and selenium is superior to Serenoa repens alone in reducing benign prostatic hyperplasia]

Urologia. Oct-Dec 2011;78(4):297-9. doi: 10.5301/RU.2011.8520.
[Article in Italian]

Abstract

Serenoa repens (SeR) is frequently associated with other natural compounds, such as lycopene (Ly), a carotenoid, and selenium (Se), an essential trace element, to increase its therapeutic activity in benign prostatic hyperplasia (BPH). The LY-Se-SeR association has a greater and stronger anti-inflammatory activity than SeR alone. In addition, the LY-Se-SeR combination is more effective than SeR alone in reducing prostate weight and hyperplasia, augmenting apoptosis, and reducing cell proliferation and growth factor expression. This experimental evidence suggests that Ly-Se-SeR association is superior to SeR alone in reducing benign prostate growth.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / therapeutic use*
  • Apoptosis / drug effects
  • Carotenoids / administration & dosage
  • Carotenoids / therapeutic use*
  • Cell Division / drug effects
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Drug Therapy, Combination
  • Epidermal Growth Factor / biosynthesis
  • Lycopene
  • Male
  • Organ Size / drug effects
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / therapeutic use*
  • Prostate / drug effects
  • Prostate / metabolism
  • Prostate / pathology
  • Prostatic Hyperplasia / drug therapy*
  • Random Allocation
  • Rats
  • Selenium / administration & dosage
  • Selenium / therapeutic use*
  • Serenoa*
  • Urinary Bladder Neck Obstruction / drug therapy
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • Anti-Inflammatory Agents
  • Plant Extracts
  • Vascular Endothelial Growth Factor A
  • vascular endothelial growth factor A, rat
  • Carotenoids
  • Epidermal Growth Factor
  • Selenium
  • Lycopene