Cilengitide induces autophagy-mediated cell death in glioma cells

Neuro Oncol. 2011 Aug;13(8):857-65. doi: 10.1093/neuonc/nor073. Epub 2011 Jul 25.


We studied the effect of the integrin inhibitor cilengitide in glioma cells. Cilengitide induced cell detachment and decreased cell viability, and induction of autophagy followed by cell apoptosis. In addition, cilengitide decreased the cell renewal of glioma stem-like cells (GSCs). Inhibition of autophagy decreased the cytotoxic effect of cilengitide. Pretreatment of glioma cells and GSCs with cilengitide prior to γ-irradiation resulted in a larger increase in autophagy and a more significant decrease in cell survival. We found that cilengitide induced autophagy collectively in glioma cells, xenografts, and GSCs, which contributed to its cytotoxic effects and sensitized these cells to γ-radiation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autophagy / drug effects*
  • Autophagy / radiation effects
  • Blotting, Western
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / pathology
  • Brain Neoplasms / radiotherapy
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Proliferation / radiation effects
  • Combined Modality Therapy
  • Gamma Rays
  • Glioma / drug therapy*
  • Glioma / pathology
  • Glioma / radiotherapy
  • Humans
  • Neoplastic Stem Cells / drug effects*
  • Neoplastic Stem Cells / radiation effects
  • Radiation-Sensitizing Agents / therapeutic use*
  • Rats
  • Rats, Nude
  • Snake Venoms / therapeutic use*
  • Transplantation, Heterologous


  • Radiation-Sensitizing Agents
  • Snake Venoms
  • Cilengitide