Hormone therapy in the management of prostate cancer: evidence-based approaches

Ther Adv Urol. 2010 Aug;2(4):171-81. doi: 10.1177/1756287210375270.


Hormonal therapy has been the standard for advanced prostate cancer for over 60 years. Recently, the utility of androgen ablation through various means has been demonstrated for earlier stages of disease. In particular, the strongest evidence to date involves the use of hormonal therapy in combination with radiation therapy. In this article we review the basic concepts in hormonal ablation for prostate cancer and review the evidence-based studies that support the use of hormonal therapy in early stage prostate cancer.

Keywords: androgen deprivation therapy; combined androgen blockade; hormonal therapy; prostate cancer.