Bacterial subversion of host actin dynamics at the plasma membrane

Cell Microbiol. 2011 Oct;13(10):1460-9. doi: 10.1111/j.1462-5822.2011.01651.x. Epub 2011 Aug 31.


Invasion of non-phagocytic cells by a number of bacterial pathogens involves the subversion of the actin cytoskeletal remodelling machinery to produce actin-rich cell surface projections designed to engulf the bacteria. The signalling that occurs to induce these actin-rich structures has considerable overlap among a diverse group of bacteria. The molecular organization within these structures act in concert to internalize the invading pathogen. This dynamic process could be subdivided into three acts - actin recruitment, engulfment, and finally, actin disassembly/internalization. This review will present the current state of knowledge of the molecular processes involved in each stage of bacterial invasion, and provide a perspective that highlights the temporal and spatial control of actin remodelling that occurs during bacterial invasion.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actins / metabolism*
  • Bacteria / pathogenicity*
  • Cell Membrane / metabolism*
  • Endocytosis*
  • Host-Pathogen Interactions*
  • Signal Transduction


  • Actins