ABO blood group and chronic pancreatitis risk in the NAPS2 cohort

Pancreas. 2011 Nov;40(8):1188-94. doi: 10.1097/MPA.0b013e3182232975.


Objectives: A risk association has been observed between non-O blood groups and pancreatic adenocarcinoma. Chronic pancreatitis also increases risk for pancreatic cancer, raising questions as to whether non-O blood groups are a risk for chronic pancreatitis and whether the pathophysiologic pathways are linked. Our goal was to determine whether ABO blood group may affect the risk of chronic pancreatitis.

Methods: The study cohort included chronic pancreatitis patients (n = 499) and healthy controls (n = 631) from the North American Pancreatitis Study 2 study. Genotyping was performed using Sequenom assay of rs8176746 A/C and rs505922 C/T to classify participants into ABO blood groups.

Results: O blood group was nonsignificantly more common among cases (44.7% vs 42.0%; P = 0.36), particularly among cases with alcohol-related chronic pancreatitis (49.3% vs 42%; P = 0.060). Alcoholic patients without coexisting high-risk PRSS1, CFTR, or SPINK1 variants had a significant overrepresentation of O blood type when compared with controls (odds ratio, 1.54; 95% confidence interval, 1.09-2.17; P = 0.01).

Conclusions: A, B, and AB blood groups were not associated with a greater likelihood of having chronic pancreatitis and may decrease the risk of chronic pancreatitis in individuals who are very heavy drinkers. These results suggest that the mechanism linking non-O blood type with pancreatic pathology is specific to carcinogenesis.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • ABO Blood-Group System / genetics*
  • Adult
  • Aged
  • Alcoholism / complications
  • Carrier Proteins / genetics
  • Cohort Studies
  • Cystic Fibrosis Transmembrane Conductance Regulator / genetics
  • DNA Mutational Analysis
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • North America
  • Odds Ratio
  • Pancreatitis, Alcoholic / etiology
  • Pancreatitis, Alcoholic / genetics*
  • Pancreatitis, Chronic / etiology
  • Pancreatitis, Chronic / genetics*
  • Risk Factors
  • Trypsin / genetics
  • Trypsin Inhibitor, Kazal Pancreatic


  • ABO Blood-Group System
  • CFTR protein, human
  • Carrier Proteins
  • SPINK1 protein, human
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • Trypsin Inhibitor, Kazal Pancreatic
  • PRSS1 protein, human
  • Trypsin