Messages in spike timing-dependent plasticity: pros and cons

Chin J Physiol. 2010 Dec 31;53(6):359-63. doi: 10.4077/cjp.2010.amm035.


Spike-timing dependent plasticity (STDP), a synaptic modification depending on a relative timing of presynaptic and postsynaptic spikes, has fascinated researchers in the fields of neurophysiology and computational neuroscience, because it is not only conceptually simple or biologically reasonable but is also versatile in neural network simulations. The STDP rule may be valid only under specific conditions, however. We propose herein a method that could find more natural and potent rules of synaptic plasticity.

Publication types

  • Review

MeSH terms

  • Action Potentials / physiology*
  • Animals
  • Humans
  • Long-Term Potentiation / physiology
  • Neuronal Plasticity / physiology*
  • Receptors, N-Methyl-D-Aspartate / physiology
  • Synapses / physiology*
  • Time Factors


  • Receptors, N-Methyl-D-Aspartate