Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Aug;51(7):626-34.
doi: 10.1080/10408391003748100.

The Bioactivity of Pomegranate: Impact on Health and Disease


The Bioactivity of Pomegranate: Impact on Health and Disease

Ana Faria et al. Crit Rev Food Sci Nutr. .


The aim of the present review is to discuss the cumulative evidence that suggests that pomegranate consumption possesses a diverse array of biological actions and may be helpful in the prevention of some inflammatory-mediated diseases including cancer. The pomegranate fruit can be divided into at least three parts-seeds, peel, and juice. All these components have been studied for their antioxidant properties in a chemoprevention approach. Pomegranate exerts antiproliferative, anti-invasive, and antimetastatic effects, induces apoptosis through modulation of Bcl-2 proteins, increases p21 and p27, and downregulates cyclin-cdk network. In addition, pomegranate inhibits the activation of inflammatory pathways including, but not limited to, the NFκ-B pathway. Anti-cancer effects with the most impressive data have been demonstrated so far in prostate cancer.

Similar articles

See all similar articles

Cited by 31 articles

See all "Cited by" articles

LinkOut - more resources