Abstract
Antibiotic resistance issues necessitate the continued discovery and development of new antibacterial agents. Efforts are ongoing in two approaches to find new compounds that are effective against antibiotic-resistant pathogens. These efforts involve modification of existing classes including fluoroquinolones, tetracyclines, aminoglycosides, and β-lactams and identification of inhibitors against previously unexploited antibacterial targets. Examples of both approaches are described here with emphasis on compounds in late pre-clinical or clinical stages of development.
Copyright © 2011. Published by Elsevier Inc.
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology
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Antimicrobial Cationic Peptides / pharmacology
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Antimicrobial Cationic Peptides / physiology
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Cell Wall / drug effects
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DNA Replication / drug effects
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DNA, Bacterial / antagonists & inhibitors
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DNA, Bacterial / biosynthesis
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Drug Resistance, Bacterial*
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Fatty Acids / antagonists & inhibitors
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Fatty Acids / biosynthesis
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Humans
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Multidrug Resistance-Associated Proteins / antagonists & inhibitors
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Protein Synthesis Inhibitors / chemistry
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Protein Synthesis Inhibitors / pharmacology
Substances
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Anti-Bacterial Agents
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Antimicrobial Cationic Peptides
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DNA, Bacterial
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Fatty Acids
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Multidrug Resistance-Associated Proteins
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Protein Synthesis Inhibitors